Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice

Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1988
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189698/
https://www.ncbi.nlm.nih.gov/pubmed/3290384
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collection PubMed
description Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-alpha was administered in combination with a nonlethal dose of rIL-1 alpha or rIL-1 beta, respectively. A similar rTNF-alpha enhancing effect of the rIL-1 was observed on the temperature response. The results show that the rIL-1 markedly potentiate the effects of rTNF-alpha on lethality and temperature in mice, and support our suggestion that TNF-alpha and IL-1 may have synergistic lethal effect in human septic shock.
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spelling pubmed-21896982008-04-17 Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice J Exp Med Articles Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-alpha was administered in combination with a nonlethal dose of rIL-1 alpha or rIL-1 beta, respectively. A similar rTNF-alpha enhancing effect of the rIL-1 was observed on the temperature response. The results show that the rIL-1 markedly potentiate the effects of rTNF-alpha on lethality and temperature in mice, and support our suggestion that TNF-alpha and IL-1 may have synergistic lethal effect in human septic shock. The Rockefeller University Press 1988-06-01 /pmc/articles/PMC2189698/ /pubmed/3290384 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
title Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
title_full Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
title_fullStr Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
title_full_unstemmed Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
title_short Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
title_sort interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189698/
https://www.ncbi.nlm.nih.gov/pubmed/3290384

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