Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses

Mice immunized with more SRBC than are required to produce optimal delayed-type hypersensitivity reactions, developed good antibody responses and poor delayed foot pad reactions. Cyclophosphamide treatment in low doses (20 mg/kg) before immunization, augmented the delayed-type hypersensitivity witho...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189708/
https://www.ncbi.nlm.nih.gov/pubmed/1117258
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collection PubMed
description Mice immunized with more SRBC than are required to produce optimal delayed-type hypersensitivity reactions, developed good antibody responses and poor delayed foot pad reactions. Cyclophosphamide treatment in low doses (20 mg/kg) before immunization, augmented the delayed-type hypersensitivity without affecting antibody responses. Cyclophosphamide did not augment delayed responses to optimal doses of SRBC (0.01%), but did augment the delayed hypersensitivity response of mice immunized with a suboptimal antigen dose (0.001%); which produced no detectable antibody response with or without cyclophosphamide pretreatment. These results suggest that antibody feedback is not the sole regulator of delayed reactions; the possibility that suppressor T cells may also be involved is discussed.
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spelling pubmed-21897082008-04-17 Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses J Exp Med Articles Mice immunized with more SRBC than are required to produce optimal delayed-type hypersensitivity reactions, developed good antibody responses and poor delayed foot pad reactions. Cyclophosphamide treatment in low doses (20 mg/kg) before immunization, augmented the delayed-type hypersensitivity without affecting antibody responses. Cyclophosphamide did not augment delayed responses to optimal doses of SRBC (0.01%), but did augment the delayed hypersensitivity response of mice immunized with a suboptimal antigen dose (0.001%); which produced no detectable antibody response with or without cyclophosphamide pretreatment. These results suggest that antibody feedback is not the sole regulator of delayed reactions; the possibility that suppressor T cells may also be involved is discussed. The Rockefeller University Press 1975-03-01 /pmc/articles/PMC2189708/ /pubmed/1117258 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
title Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
title_full Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
title_fullStr Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
title_full_unstemmed Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
title_short Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
title_sort augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189708/
https://www.ncbi.nlm.nih.gov/pubmed/1117258

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