Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice

Ribonuclease activity in cell-free thymus homogenates was elevated for five strains of mice genetically predisposed toward leukemia or reticulum cell neoplasms (AKR, C58, PL, RF, and SJL). Such increased activity was directed against polyuridylic acid and was observed in 8- wk old mice, well before...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189743/
https://www.ncbi.nlm.nih.gov/pubmed/1092792
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collection PubMed
description Ribonuclease activity in cell-free thymus homogenates was elevated for five strains of mice genetically predisposed toward leukemia or reticulum cell neoplasms (AKR, C58, PL, RF, and SJL). Such increased activity was directed against polyuridylic acid and was observed in 8- wk old mice, well before the onset of neoplastic transformation. Similarly, white blood cell ribonuclease activity was elevated in mice of the strains AKR, C2H/He, PL and RF. Statistical analysis indicated that such elevated activity in these strains related to their high incidence of spontaneous neoplastic disease. Elevated ribonuclease activity thus represents a new biochemical marker relating to the genetic propensity of some strains of mice to die prematurely of spontaneous neoplasia.
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spelling pubmed-21897432008-04-17 Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice J Exp Med Articles Ribonuclease activity in cell-free thymus homogenates was elevated for five strains of mice genetically predisposed toward leukemia or reticulum cell neoplasms (AKR, C58, PL, RF, and SJL). Such increased activity was directed against polyuridylic acid and was observed in 8- wk old mice, well before the onset of neoplastic transformation. Similarly, white blood cell ribonuclease activity was elevated in mice of the strains AKR, C2H/He, PL and RF. Statistical analysis indicated that such elevated activity in these strains related to their high incidence of spontaneous neoplastic disease. Elevated ribonuclease activity thus represents a new biochemical marker relating to the genetic propensity of some strains of mice to die prematurely of spontaneous neoplasia. The Rockefeller University Press 1975-04-01 /pmc/articles/PMC2189743/ /pubmed/1092792 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
title Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
title_full Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
title_fullStr Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
title_full_unstemmed Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
title_short Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
title_sort elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189743/
https://www.ncbi.nlm.nih.gov/pubmed/1092792

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