X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells

A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus- dependent (T) lymphocytes w...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189753/
https://www.ncbi.nlm.nih.gov/pubmed/805203
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description A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus- dependent (T) lymphocytes were normal. The X-linked nature of the immune defect in these mice was therefore attributed to abnormal or absent B lymphocytes. The possible nature of this defect and the similarity of the immune defect in these mice to certain human X-linked immunodeficiency diseases are discussed.
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spelling pubmed-21897532008-04-17 X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells J Exp Med Articles A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus- dependent (T) lymphocytes were normal. The X-linked nature of the immune defect in these mice was therefore attributed to abnormal or absent B lymphocytes. The possible nature of this defect and the similarity of the immune defect in these mice to certain human X-linked immunodeficiency diseases are discussed. The Rockefeller University Press 1975-04-01 /pmc/articles/PMC2189753/ /pubmed/805203 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
title X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
title_full X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
title_fullStr X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
title_full_unstemmed X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
title_short X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
title_sort x-linked b-lymphocyte immune defect in cba/hn mice. i. studies of the function and composition of spleen cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189753/
https://www.ncbi.nlm.nih.gov/pubmed/805203

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