Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system

A significant within-strain correlation has been demonstrated between the levels of Ss and hemolytic complement (C) activity in two Ss-high strains. Mouse serum specifically depleted of Ss by absorption with F(ab')2 fragments of anti-Ss had negligible C activity. In control experiments, Ss-spec...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189786/
https://www.ncbi.nlm.nih.gov/pubmed/805206
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description A significant within-strain correlation has been demonstrated between the levels of Ss and hemolytic complement (C) activity in two Ss-high strains. Mouse serum specifically depleted of Ss by absorption with F(ab')2 fragments of anti-Ss had negligible C activity. In control experiments, Ss-specific antigen-antibody complexes formed with F(ab')2 fragments did not fix rabbit C, and bovine serum albumin-specific antigen-antibody complexes formed with F(ab')2 fragments did not fix mouse C. Therefore the removal of C activity by anti-Ss [F(ab')2] was apparently not due to C fixation. These results suggest that the Ss protein is a necessary component of the C system.
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spelling pubmed-21897862008-04-17 Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system J Exp Med Articles A significant within-strain correlation has been demonstrated between the levels of Ss and hemolytic complement (C) activity in two Ss-high strains. Mouse serum specifically depleted of Ss by absorption with F(ab')2 fragments of anti-Ss had negligible C activity. In control experiments, Ss-specific antigen-antibody complexes formed with F(ab')2 fragments did not fix rabbit C, and bovine serum albumin-specific antigen-antibody complexes formed with F(ab')2 fragments did not fix mouse C. Therefore the removal of C activity by anti-Ss [F(ab')2] was apparently not due to C fixation. These results suggest that the Ss protein is a necessary component of the C system. The Rockefeller University Press 1975-05-01 /pmc/articles/PMC2189786/ /pubmed/805206 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
title Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
title_full Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
title_fullStr Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
title_full_unstemmed Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
title_short Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system
title_sort evidence for the involvement of the ss protein of the mouse in the hemolytic complement system
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189786/
https://www.ncbi.nlm.nih.gov/pubmed/805206

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