Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis

Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189878/
https://www.ncbi.nlm.nih.gov/pubmed/50401
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collection PubMed
description Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein-induced (secondary) amyloid fibrils. This antiserum to the amyloid fibril protein AA (mol wt 8,400 daltons) detects an immunologically cross-reacting serum alpha globulin (SAA) (mol wt approx. 100,000). It is postulated that the serum factor (SAA) is a regulator of antibody response and may be present in elevated amounts as the result of chronic antigenic stimulation.
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spelling pubmed-21898782008-04-17 Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis J Exp Med Articles Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein-induced (secondary) amyloid fibrils. This antiserum to the amyloid fibril protein AA (mol wt 8,400 daltons) detects an immunologically cross-reacting serum alpha globulin (SAA) (mol wt approx. 100,000). It is postulated that the serum factor (SAA) is a regulator of antibody response and may be present in elevated amounts as the result of chronic antigenic stimulation. The Rockefeller University Press 1975-07-01 /pmc/articles/PMC2189878/ /pubmed/50401 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis
title Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis
title_full Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis
title_fullStr Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis
title_full_unstemmed Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis
title_short Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis
title_sort suppression of in vitro antibody response by a serum factor (saa) in experimentally induced amyloidosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189878/
https://www.ncbi.nlm.nih.gov/pubmed/50401

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