Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera

Human sera were tested for cytotoxicity to pairs of long-term tissue- cultured cell lines. Each pair had been derived from the same individual and one of the pairs possessed the characteristics of either "T" or "B" cells. The alloantisera used were HL-A-typing reagents or sera ob...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189880/
https://www.ncbi.nlm.nih.gov/pubmed/1080182
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description Human sera were tested for cytotoxicity to pairs of long-term tissue- cultured cell lines. Each pair had been derived from the same individual and one of the pairs possessed the characteristics of either "T" or "B" cells. The alloantisera used were HL-A-typing reagents or sera obtained from Amish multiparas. Selected cytotoxicity was found against the B-cell lines by direct testing. Cytotoxicity was abolished by absorption with B-cell line but not by absorption with the T-cell lines. The results suggest that a group of allotypic antigens may be expressed exculsively on human B cells.
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spelling pubmed-21898802008-04-17 Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera J Exp Med Articles Human sera were tested for cytotoxicity to pairs of long-term tissue- cultured cell lines. Each pair had been derived from the same individual and one of the pairs possessed the characteristics of either "T" or "B" cells. The alloantisera used were HL-A-typing reagents or sera obtained from Amish multiparas. Selected cytotoxicity was found against the B-cell lines by direct testing. Cytotoxicity was abolished by absorption with B-cell line but not by absorption with the T-cell lines. The results suggest that a group of allotypic antigens may be expressed exculsively on human B cells. The Rockefeller University Press 1975-07-01 /pmc/articles/PMC2189880/ /pubmed/1080182 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera
title Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera
title_full Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera
title_fullStr Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera
title_full_unstemmed Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera
title_short Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera
title_sort detection of antigens specific for b-lymphoid cultured cell lines with human alloantisera
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189880/
https://www.ncbi.nlm.nih.gov/pubmed/1080182

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