Fibroblast surface antigen produced but not retained by virus- transformed human cells

Normal human fibroblasts contain a cell type-specific glycoprotein antigen (SF) that is known to be slowly shed into the medium and to be present also in human serum. Immunofluorescence with anti-SF antibodies showed that SF antigen has a highly nonrandom fibrillar distribution in surface of normal...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189896/
https://www.ncbi.nlm.nih.gov/pubmed/167099
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collection PubMed
description Normal human fibroblasts contain a cell type-specific glycoprotein antigen (SF) that is known to be slowly shed into the medium and to be present also in human serum. Immunofluorescence with anti-SF antibodies showed that SF antigen has a highly nonrandom fibrillar distribution in surface of normal fibroblasts. Simian virus 40- transformed fibroblasts also produced the SF antigen, as shown by radioimmunoassay or immunodiffusion tests, but it was not retained by the surface of these cells. This creates a major difference between the surfaces of normal and malignant cells.
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spelling pubmed-21898962008-04-17 Fibroblast surface antigen produced but not retained by virus- transformed human cells J Exp Med Articles Normal human fibroblasts contain a cell type-specific glycoprotein antigen (SF) that is known to be slowly shed into the medium and to be present also in human serum. Immunofluorescence with anti-SF antibodies showed that SF antigen has a highly nonrandom fibrillar distribution in surface of normal fibroblasts. Simian virus 40- transformed fibroblasts also produced the SF antigen, as shown by radioimmunoassay or immunodiffusion tests, but it was not retained by the surface of these cells. This creates a major difference between the surfaces of normal and malignant cells. The Rockefeller University Press 1975-08-01 /pmc/articles/PMC2189896/ /pubmed/167099 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Fibroblast surface antigen produced but not retained by virus- transformed human cells
title Fibroblast surface antigen produced but not retained by virus- transformed human cells
title_full Fibroblast surface antigen produced but not retained by virus- transformed human cells
title_fullStr Fibroblast surface antigen produced but not retained by virus- transformed human cells
title_full_unstemmed Fibroblast surface antigen produced but not retained by virus- transformed human cells
title_short Fibroblast surface antigen produced but not retained by virus- transformed human cells
title_sort fibroblast surface antigen produced but not retained by virus- transformed human cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189896/
https://www.ncbi.nlm.nih.gov/pubmed/167099

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