The ontogeny of antigen-specific T cells

Although the fetal lamb is unable to form circulating antiovalbumin antibodies until about 120 days of gestation, ovalbumin-specific helper T cells can be stimulated to function at an earlier age. This would suggest that the critical event responsible for the precise sequential maturation of immunol...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189928/
https://www.ncbi.nlm.nih.gov/pubmed/1080789
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description Although the fetal lamb is unable to form circulating antiovalbumin antibodies until about 120 days of gestation, ovalbumin-specific helper T cells can be stimulated to function at an earlier age. This would suggest that the critical event responsible for the precise sequential maturation of immunologic competence to different antigens at different developmental stages is not the first appearance of specific receptors on immunocytes. Alternative explanations of this phenomenon are discussed.
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spelling pubmed-21899282008-04-17 The ontogeny of antigen-specific T cells J Exp Med Articles Although the fetal lamb is unable to form circulating antiovalbumin antibodies until about 120 days of gestation, ovalbumin-specific helper T cells can be stimulated to function at an earlier age. This would suggest that the critical event responsible for the precise sequential maturation of immunologic competence to different antigens at different developmental stages is not the first appearance of specific receptors on immunocytes. Alternative explanations of this phenomenon are discussed. The Rockefeller University Press 1975-09-01 /pmc/articles/PMC2189928/ /pubmed/1080789 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The ontogeny of antigen-specific T cells
title The ontogeny of antigen-specific T cells
title_full The ontogeny of antigen-specific T cells
title_fullStr The ontogeny of antigen-specific T cells
title_full_unstemmed The ontogeny of antigen-specific T cells
title_short The ontogeny of antigen-specific T cells
title_sort ontogeny of antigen-specific t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189928/
https://www.ncbi.nlm.nih.gov/pubmed/1080789

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