Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages

Peritoneal macrophages from mice infected with Bacille Calmette-Guerin (BCG) and from normal mice were examined for their effects in vitro on thymidine uptake by 10 murine lymphomas, a murine fibroblast line, and a guinea pig hepatoma. Only the murine fibroblast line showed growth inhibition in the...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189947/
https://www.ncbi.nlm.nih.gov/pubmed/170358
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description Peritoneal macrophages from mice infected with Bacille Calmette-Guerin (BCG) and from normal mice were examined for their effects in vitro on thymidine uptake by 10 murine lymphomas, a murine fibroblast line, and a guinea pig hepatoma. Only the murine fibroblast line showed growth inhibition in the presence of BCG macrophages. For the majority of tumors, normal macrophages were profoundly stimulatory to tumor cell DNA synthesis, while BCG macrophages were much less stimulatory, without being frankly inhibitory. The effect of 2-mercaptoethanol on tumor cell growth was also studied. All lymphomas stimulated to grow more rapidly in vitro by normal macrophages were stimulated to a similar degree by 2-mercaptoethanol.
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spelling pubmed-21899472008-04-17 Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages J Exp Med Articles Peritoneal macrophages from mice infected with Bacille Calmette-Guerin (BCG) and from normal mice were examined for their effects in vitro on thymidine uptake by 10 murine lymphomas, a murine fibroblast line, and a guinea pig hepatoma. Only the murine fibroblast line showed growth inhibition in the presence of BCG macrophages. For the majority of tumors, normal macrophages were profoundly stimulatory to tumor cell DNA synthesis, while BCG macrophages were much less stimulatory, without being frankly inhibitory. The effect of 2-mercaptoethanol on tumor cell growth was also studied. All lymphomas stimulated to grow more rapidly in vitro by normal macrophages were stimulated to a similar degree by 2-mercaptoethanol. The Rockefeller University Press 1975-10-01 /pmc/articles/PMC2189947/ /pubmed/170358 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
title Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
title_full Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
title_fullStr Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
title_full_unstemmed Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
title_short Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages
title_sort differential stimulation of murine lymphoma growth in vitro by normal and bcg-activated macrophages
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189947/
https://www.ncbi.nlm.nih.gov/pubmed/170358

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