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Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies
Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of anti...
| Formato: | Texto |
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| Lenguaje: | English |
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The Rockefeller University Press
1975
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189971/ https://www.ncbi.nlm.nih.gov/pubmed/53257 |
| _version_ | 1782146739737722880 |
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| collection | PubMed |
| description | Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of antibodies that are specific for phosphorylcholine and carry the idiotypic determinants. This induction is dependent on the recognition of carrier determinants on the anti-idiotype antibody by helper T cells. We conclude that receptor antibody molecules on the surface of the precursors of antibody-forming cells deliver the antigenic signal for the induction of these cells. |
| format | Text |
| id | pubmed-2189971 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1975 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21899712008-04-17 Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies J Exp Med Articles Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of antibodies that are specific for phosphorylcholine and carry the idiotypic determinants. This induction is dependent on the recognition of carrier determinants on the anti-idiotype antibody by helper T cells. We conclude that receptor antibody molecules on the surface of the precursors of antibody-forming cells deliver the antigenic signal for the induction of these cells. The Rockefeller University Press 1975-11-01 /pmc/articles/PMC2189971/ /pubmed/53257 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Articles Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| title | Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| title_full | Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| title_fullStr | Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| title_full_unstemmed | Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| title_short | Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| title_sort | induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies |
| topic | Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189971/ https://www.ncbi.nlm.nih.gov/pubmed/53257 |