Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control

Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloi...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190064/
https://www.ncbi.nlm.nih.gov/pubmed/1104749
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collection PubMed
description Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.
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spelling pubmed-21900642008-04-17 Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control J Exp Med Articles Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation. The Rockefeller University Press 1975-12-01 /pmc/articles/PMC2190064/ /pubmed/1104749 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
title Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
title_full Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
title_fullStr Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
title_full_unstemmed Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
title_short Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control
title_sort experimental amyloidosis: the inducer is a polyclonal b-cell activator to which susceptibility is under genetic control
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190064/
https://www.ncbi.nlm.nih.gov/pubmed/1104749

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