Activated macrophages release a factor which lyses malignant cells but not normal cells

When rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. Although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. This tumor-selective lytic ef...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190066/
https://www.ncbi.nlm.nih.gov/pubmed/1194858
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collection PubMed
description When rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. Although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. This tumor-selective lytic effect is mediated by a labile supernatant product.
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spelling pubmed-21900662008-04-17 Activated macrophages release a factor which lyses malignant cells but not normal cells J Exp Med Articles When rat macrophages are activated by exposure to bacterial endotoxin they acquire the capacity to lyse sarcoma cells in tissue culture. Although showing no immunological specificity this lytic effect was only detectable on malignant cells; normal cells were unaffected. This tumor-selective lytic effect is mediated by a labile supernatant product. The Rockefeller University Press 1975-12-01 /pmc/articles/PMC2190066/ /pubmed/1194858 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Activated macrophages release a factor which lyses malignant cells but not normal cells
title Activated macrophages release a factor which lyses malignant cells but not normal cells
title_full Activated macrophages release a factor which lyses malignant cells but not normal cells
title_fullStr Activated macrophages release a factor which lyses malignant cells but not normal cells
title_full_unstemmed Activated macrophages release a factor which lyses malignant cells but not normal cells
title_short Activated macrophages release a factor which lyses malignant cells but not normal cells
title_sort activated macrophages release a factor which lyses malignant cells but not normal cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190066/
https://www.ncbi.nlm.nih.gov/pubmed/1194858

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