Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells

Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190104/
https://www.ncbi.nlm.nih.gov/pubmed/53267
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collection PubMed
description Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by cross-reacting antisera.
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spelling pubmed-21901042008-04-17 Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells J Exp Med Articles Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by cross-reacting antisera. The Rockefeller University Press 1976-01-01 /pmc/articles/PMC2190104/ /pubmed/53267 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells
title Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells
title_full Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells
title_fullStr Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells
title_full_unstemmed Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells
title_short Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells
title_sort expression of individual ia specificities on t and b cells. i. studies with mitogen-induced blast cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190104/
https://www.ncbi.nlm.nih.gov/pubmed/53267

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