Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells

A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome. Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190108/
https://www.ncbi.nlm.nih.gov/pubmed/53268
_version_ 1782146752335314944
collection PubMed
description A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome. Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term culture. Cells taken from the tumors were nearly triploid, retained all human chromosome markers, and had the same antigenic determinants(s) as cells in culture.
format Text
id pubmed-2190108
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21901082008-04-17 Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells J Exp Med Articles A new animal model characterized by hereditary athymia and asplenia was used as a recipient of chronic myelogenous leukemic (CML) cells with the Philadelphia (Ph1+) chromosome. Transplanted CML cells form solid vascularized tumors containing cells similar to those seen in the patient in a long-term culture. Cells taken from the tumors were nearly triploid, retained all human chromosome markers, and had the same antigenic determinants(s) as cells in culture. The Rockefeller University Press 1976-01-01 /pmc/articles/PMC2190108/ /pubmed/53268 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
title Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
title_full Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
title_fullStr Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
title_full_unstemmed Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
title_short Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
title_sort hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190108/
https://www.ncbi.nlm.nih.gov/pubmed/53268

Ejemplares similares