Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities

The effect of preimmunization of CBA/H mice with M locus and H-2 incompatible lymphocytes was examined on the in vitro generation of cytotoxic cells to both types of targets. Preimmunization with M locus did not help to generate cytotoxic cells to M-locus targets; however, the anti-H-2 cytotoxicity...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190111/
https://www.ncbi.nlm.nih.gov/pubmed/55455
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collection PubMed
description The effect of preimmunization of CBA/H mice with M locus and H-2 incompatible lymphocytes was examined on the in vitro generation of cytotoxic cells to both types of targets. Preimmunization with M locus did not help to generate cytotoxic cells to M-locus targets; however, the anti-H-2 cytotoxicity of M-locus-preimmunized lymphocytes was suppressed between the 6th and 19th day after preimmunization. In contrast, preimmunization with H-2 incompatibility produced an amplified lytic anti-H-2 response. The possible mechanisms are discussed.
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spelling pubmed-21901112008-04-17 Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities J Exp Med Articles The effect of preimmunization of CBA/H mice with M locus and H-2 incompatible lymphocytes was examined on the in vitro generation of cytotoxic cells to both types of targets. Preimmunization with M locus did not help to generate cytotoxic cells to M-locus targets; however, the anti-H-2 cytotoxicity of M-locus-preimmunized lymphocytes was suppressed between the 6th and 19th day after preimmunization. In contrast, preimmunization with H-2 incompatibility produced an amplified lytic anti-H-2 response. The possible mechanisms are discussed. The Rockefeller University Press 1976-02-01 /pmc/articles/PMC2190111/ /pubmed/55455 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities
title Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities
title_full Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities
title_fullStr Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities
title_full_unstemmed Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities
title_short Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities
title_sort modification of murine t-cell cytotoxicity by preimmunization with m locus and h-2 incompatibilities
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190111/
https://www.ncbi.nlm.nih.gov/pubmed/55455

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