Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes

Evidence is presented to support the contention that IgM demonstrable by surface immunofluorescent staining on H-2-activated T cells represents specifically adsorbed B-cell-derived alloantibody. T cells activated to H-2 determinants expressed surface IgM only when the progenitor cell populations con...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190121/
https://www.ncbi.nlm.nih.gov/pubmed/55453
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collection PubMed
description Evidence is presented to support the contention that IgM demonstrable by surface immunofluorescent staining on H-2-activated T cells represents specifically adsorbed B-cell-derived alloantibody. T cells activated to H-2 determinants expressed surface IgM only when the progenitor cell populations contained B lymphocytes. IgM was not detected on T cells activated to determinants which fail to stimulate alloantibody production (e.g., M-locus determinants). In addition, IgM- negative H-2 activated T cells (derived from B-cell-depleted lymphoid cells), unlike M-locus-activated T cells, adsorbed IgM in a specific manner when incubated in vitro with "early bleed" antisera raised against the activating H-2 determinants.
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spelling pubmed-21901212008-04-17 Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes J Exp Med Articles Evidence is presented to support the contention that IgM demonstrable by surface immunofluorescent staining on H-2-activated T cells represents specifically adsorbed B-cell-derived alloantibody. T cells activated to H-2 determinants expressed surface IgM only when the progenitor cell populations contained B lymphocytes. IgM was not detected on T cells activated to determinants which fail to stimulate alloantibody production (e.g., M-locus determinants). In addition, IgM- negative H-2 activated T cells (derived from B-cell-depleted lymphoid cells), unlike M-locus-activated T cells, adsorbed IgM in a specific manner when incubated in vitro with "early bleed" antisera raised against the activating H-2 determinants. The Rockefeller University Press 1976-02-01 /pmc/articles/PMC2190121/ /pubmed/55453 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes
title Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes
title_full Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes
title_fullStr Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes
title_full_unstemmed Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes
title_short Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes
title_sort specific adsorption of igm antibody onto h-2-activated mouse t lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190121/
https://www.ncbi.nlm.nih.gov/pubmed/55453

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