Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages

Genetic resistance to mouse hepatitis, which resides largely in the macrophages of resistant C3H mice, may be altered by exposing the cells in vitro to fluid from allogeneic mixed lymphocytes. A 1,000-fold increase in susceptibility was produced in these genetically resistant cells by exposure to th...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190139/
https://www.ncbi.nlm.nih.gov/pubmed/175127
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description Genetic resistance to mouse hepatitis, which resides largely in the macrophages of resistant C3H mice, may be altered by exposing the cells in vitro to fluid from allogeneic mixed lymphocytes. A 1,000-fold increase in susceptibility was produced in these genetically resistant cells by exposure to this fluid. This presumed lymphokine was effective without producing any change in host adaption of the virus.
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spelling pubmed-21901392008-04-17 Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages J Exp Med Articles Genetic resistance to mouse hepatitis, which resides largely in the macrophages of resistant C3H mice, may be altered by exposing the cells in vitro to fluid from allogeneic mixed lymphocytes. A 1,000-fold increase in susceptibility was produced in these genetically resistant cells by exposure to this fluid. This presumed lymphokine was effective without producing any change in host adaption of the virus. The Rockefeller University Press 1976-03-01 /pmc/articles/PMC2190139/ /pubmed/175127 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
title Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
title_full Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
title_fullStr Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
title_full_unstemmed Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
title_short Macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
title_sort macrophages genetically resistant to mouse hepatitis virus converted in vitro to susceptible macrophages
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190139/
https://www.ncbi.nlm.nih.gov/pubmed/175127

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