Evidence for direct linkage between antigen recognition and lytic expression in effector T cells

The relationship between antigen recognition and lytic expression by effector T cells was examined by coculturing two cytolytically active lymphoid cell populations. When antigen recognition between the populations could occur only in one direction, then cytotoxicity was expressed only in that direc...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190140/
https://www.ncbi.nlm.nih.gov/pubmed/1082495
_version_ 1782146759395377152
collection PubMed
description The relationship between antigen recognition and lytic expression by effector T cells was examined by coculturing two cytolytically active lymphoid cell populations. When antigen recognition between the populations could occur only in one direction, then cytotoxicity was expressed only in that direction and the population whose antigens were recognized lost its lytic activity. In contrast, the cocultured effector cell population fully maintained its lytic potential. This lack of reciprocal inactivation was taken as evidence that T-cell receptor accomodation by surface antigen is linked to the expression of cytolytic activity by effector T lymphocytes.
format Text
id pubmed-2190140
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21901402008-04-17 Evidence for direct linkage between antigen recognition and lytic expression in effector T cells J Exp Med Articles The relationship between antigen recognition and lytic expression by effector T cells was examined by coculturing two cytolytically active lymphoid cell populations. When antigen recognition between the populations could occur only in one direction, then cytotoxicity was expressed only in that direction and the population whose antigens were recognized lost its lytic activity. In contrast, the cocultured effector cell population fully maintained its lytic potential. This lack of reciprocal inactivation was taken as evidence that T-cell receptor accomodation by surface antigen is linked to the expression of cytolytic activity by effector T lymphocytes. The Rockefeller University Press 1976-03-01 /pmc/articles/PMC2190140/ /pubmed/1082495 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Evidence for direct linkage between antigen recognition and lytic expression in effector T cells
title Evidence for direct linkage between antigen recognition and lytic expression in effector T cells
title_full Evidence for direct linkage between antigen recognition and lytic expression in effector T cells
title_fullStr Evidence for direct linkage between antigen recognition and lytic expression in effector T cells
title_full_unstemmed Evidence for direct linkage between antigen recognition and lytic expression in effector T cells
title_short Evidence for direct linkage between antigen recognition and lytic expression in effector T cells
title_sort evidence for direct linkage between antigen recognition and lytic expression in effector t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190140/
https://www.ncbi.nlm.nih.gov/pubmed/1082495

Ejemplares similares