Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells

Immune spleen cells from LCM virus-infected (CBA X C57BL/6)F1 radiation chimeras entirely repopulated with CBA-T6 lymphocytes were cytotoxic for allogeneic, LCM virus infected C57BL/6 mouse-derived target cells. Normal C57BL/6 targets were not lysed. CBA-T6 lymphocytes derived from (CBA X C57BL/6) r...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190159/
https://www.ncbi.nlm.nih.gov/pubmed/1082923
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collection PubMed
description Immune spleen cells from LCM virus-infected (CBA X C57BL/6)F1 radiation chimeras entirely repopulated with CBA-T6 lymphocytes were cytotoxic for allogeneic, LCM virus infected C57BL/6 mouse-derived target cells. Normal C57BL/6 targets were not lysed. CBA-T6 lymphocytes derived from (CBA X C57BL/6) radiation chimeras sensitized in vitro against TNP- conjugated C57BL/6 spleen cells lysed TNP-conjugated C57BL/6 targets. However normal C57BL/6 mouse-derived targets were not destroyed. The magnitude of virus-specific (or TNP-specific) cytotoxic responses against H-2 incompatible targets was lower compared to that against H-2 compatible targets. These data are considered to support and to extend the altered self concept, but are not consistent with the dual recognition concept.
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spelling pubmed-21901592008-04-17 Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells J Exp Med Articles Immune spleen cells from LCM virus-infected (CBA X C57BL/6)F1 radiation chimeras entirely repopulated with CBA-T6 lymphocytes were cytotoxic for allogeneic, LCM virus infected C57BL/6 mouse-derived target cells. Normal C57BL/6 targets were not lysed. CBA-T6 lymphocytes derived from (CBA X C57BL/6) radiation chimeras sensitized in vitro against TNP- conjugated C57BL/6 spleen cells lysed TNP-conjugated C57BL/6 targets. However normal C57BL/6 mouse-derived targets were not destroyed. The magnitude of virus-specific (or TNP-specific) cytotoxic responses against H-2 incompatible targets was lower compared to that against H-2 compatible targets. These data are considered to support and to extend the altered self concept, but are not consistent with the dual recognition concept. The Rockefeller University Press 1976-04-01 /pmc/articles/PMC2190159/ /pubmed/1082923 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells
title Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells
title_full Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells
title_fullStr Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells
title_full_unstemmed Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells
title_short Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells
title_sort virus and trinitrophenol hapten-specific t-cell-mediated cytotoxicity against h-2 incompatible target cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190159/
https://www.ncbi.nlm.nih.gov/pubmed/1082923

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