Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes

The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly- (glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 dis...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190170/
https://www.ncbi.nlm.nih.gov/pubmed/1255115
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collection PubMed
description The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly- (glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 distributions, however, the H-2 patterns are part of a single inclusion group system. The alpha- and beta-genes are dominant; however, most effective gene interactions occur when the two genes are in the cis configuration. The potential significance of this cis-trans effect is discussed.
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spelling pubmed-21901702008-04-17 Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes J Exp Med Articles The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly- (glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 distributions, however, the H-2 patterns are part of a single inclusion group system. The alpha- and beta-genes are dominant; however, most effective gene interactions occur when the two genes are in the cis configuration. The potential significance of this cis-trans effect is discussed. The Rockefeller University Press 1976-04-01 /pmc/articles/PMC2190170/ /pubmed/1255115 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes
title Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes
title_full Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes
title_fullStr Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes
title_full_unstemmed Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes
title_short Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes
title_sort inclusion group systems and cis-trans effects in responses controlled by the two complementing ir-glphi genes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190170/
https://www.ncbi.nlm.nih.gov/pubmed/1255115

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