A genetic polymorphism in the constant region of rabbit b4 kappa chains

Amino acid sequence analysis of a b4 light chain from a rabbit homogeneous antistreptococcal antibody revealed the presence of two amino acid substitutions in the constant region not previously reported for these positions. These interchanges, consisting of serine for alanine at position 121 and leu...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190215/
https://www.ncbi.nlm.nih.gov/pubmed/818336
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description Amino acid sequence analysis of a b4 light chain from a rabbit homogeneous antistreptococcal antibody revealed the presence of two amino acid substitutions in the constant region not previously reported for these positions. These interchanges, consisting of serine for alanine at position 121 and leucine for glutamine at position 124, were also present in about 30% of the pooled b4 light chains isolated from pooled IgG from the rabbit (4539) that produced the homogeneous antibody. In addition, these interchanges (b4var) were found, always at the same levels, in varying percentages in nonimmune or early immune bleedings from related rabbits in this pedigreed family and could be traced for five generations. The inheritance pattern of b4var was consistent with autosomal codominant inheritance.
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spelling pubmed-21902152008-04-17 A genetic polymorphism in the constant region of rabbit b4 kappa chains J Exp Med Articles Amino acid sequence analysis of a b4 light chain from a rabbit homogeneous antistreptococcal antibody revealed the presence of two amino acid substitutions in the constant region not previously reported for these positions. These interchanges, consisting of serine for alanine at position 121 and leucine for glutamine at position 124, were also present in about 30% of the pooled b4 light chains isolated from pooled IgG from the rabbit (4539) that produced the homogeneous antibody. In addition, these interchanges (b4var) were found, always at the same levels, in varying percentages in nonimmune or early immune bleedings from related rabbits in this pedigreed family and could be traced for five generations. The inheritance pattern of b4var was consistent with autosomal codominant inheritance. The Rockefeller University Press 1976-06-01 /pmc/articles/PMC2190215/ /pubmed/818336 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A genetic polymorphism in the constant region of rabbit b4 kappa chains
title A genetic polymorphism in the constant region of rabbit b4 kappa chains
title_full A genetic polymorphism in the constant region of rabbit b4 kappa chains
title_fullStr A genetic polymorphism in the constant region of rabbit b4 kappa chains
title_full_unstemmed A genetic polymorphism in the constant region of rabbit b4 kappa chains
title_short A genetic polymorphism in the constant region of rabbit b4 kappa chains
title_sort genetic polymorphism in the constant region of rabbit b4 kappa chains
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190215/
https://www.ncbi.nlm.nih.gov/pubmed/818336

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