Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen

Polymyxin B, which is a basic polypeptide produced by various strains of Bacillus Polymyxa, has previously been shown to prevent the lethal effect of LPS and to neutralize the Schwartzmann reaction. In this study we have investigated the interactions between polymyxin B and lipopolysaccharide (LPS)...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190220/
https://www.ncbi.nlm.nih.gov/pubmed/178823
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collection PubMed
description Polymyxin B, which is a basic polypeptide produced by various strains of Bacillus Polymyxa, has previously been shown to prevent the lethal effect of LPS and to neutralize the Schwartzmann reaction. In this study we have investigated the interactions between polymyxin B and lipopolysaccharide (LPS) and hapten LPS conjugates. Polymyxin B was found to suppress mitogenicity of LPS and also to inhibit immunogenicity of the hapten conjugate 4-hydroxy-3,5-dinitrophenacetyl (NNP)-LPS. Inhibition was not due to interference with the expression of NNP determinants nor to cross-reactivity between PB and the hapten. Since mitogenicity and immunogenicity decreased in parallel, we conclude that B-cell activation in specific thymus independent responses does not take place in the absence of a nonspecific (non-Ig- mediated) signal.
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spelling pubmed-21902202008-04-17 Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen J Exp Med Articles Polymyxin B, which is a basic polypeptide produced by various strains of Bacillus Polymyxa, has previously been shown to prevent the lethal effect of LPS and to neutralize the Schwartzmann reaction. In this study we have investigated the interactions between polymyxin B and lipopolysaccharide (LPS) and hapten LPS conjugates. Polymyxin B was found to suppress mitogenicity of LPS and also to inhibit immunogenicity of the hapten conjugate 4-hydroxy-3,5-dinitrophenacetyl (NNP)-LPS. Inhibition was not due to interference with the expression of NNP determinants nor to cross-reactivity between PB and the hapten. Since mitogenicity and immunogenicity decreased in parallel, we conclude that B-cell activation in specific thymus independent responses does not take place in the absence of a nonspecific (non-Ig- mediated) signal. The Rockefeller University Press 1976-06-01 /pmc/articles/PMC2190220/ /pubmed/178823 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen
title Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen
title_full Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen
title_fullStr Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen
title_full_unstemmed Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen
title_short Association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a T-independent antigen
title_sort association between mitogenicity and immunogenicity of 4-hydroxy-3,5- dinitrophenacetyl-lipopolysaccharide, a t-independent antigen
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190220/
https://www.ncbi.nlm.nih.gov/pubmed/178823

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