Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis

The leukocytosis- and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. LPF contains 14.5% nitrogen and is lipid and carbohydrate free. It is apparently composed of four polypeptide subunits....

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190226/
https://www.ncbi.nlm.nih.gov/pubmed/58054
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description The leukocytosis- and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. LPF contains 14.5% nitrogen and is lipid and carbohydrate free. It is apparently composed of four polypeptide subunits. LPF caused leukocytosis and lymphocytosis in "nude" as well as in normal mice. In addition, purified LPF also induced histamine sensitization and hypoglycemia and refractoriness to the hyperglycemic effect of epinephrine. A monospecific LPF antiserum blocked these reactions as well as leukocytosis and lymphocytosis. LPF is clearly distinct from the hemagglutinating pili of B. pertussis.
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spelling pubmed-21902262008-04-17 Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis J Exp Med Articles The leukocytosis- and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated to near homogeneity by physical, chemical, and electron microscopical criteria. LPF contains 14.5% nitrogen and is lipid and carbohydrate free. It is apparently composed of four polypeptide subunits. LPF caused leukocytosis and lymphocytosis in "nude" as well as in normal mice. In addition, purified LPF also induced histamine sensitization and hypoglycemia and refractoriness to the hyperglycemic effect of epinephrine. A monospecific LPF antiserum blocked these reactions as well as leukocytosis and lymphocytosis. LPF is clearly distinct from the hemagglutinating pili of B. pertussis. The Rockefeller University Press 1976-06-01 /pmc/articles/PMC2190226/ /pubmed/58054 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
title Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
title_full Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
title_fullStr Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
title_full_unstemmed Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
title_short Isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of Bordetella pertussis
title_sort isolation and properties of the leukocytosis- and lymphocytosis- promoting factor of bordetella pertussis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190226/
https://www.ncbi.nlm.nih.gov/pubmed/58054

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