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Pharmacokinetic–Pharmacodynamic Modeling of the Effectiveness and Safety of Buprenorphine and Fentanyl in Rats

OBJECTIVE: Respiratory depression is a serious and potentially life-threatening side-effect of opioid therapy. The objective of this investigation was to characterize the relationship between buprenorphine or fentanyl exposure and the effectiveness and safety outcome in rats. METHODS: Data on the ti...

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Detalles Bibliográficos
Autores principales:	Yassen, Ashraf, Olofsen, Erik, Kan, Jingmin, Dahan, Albert, Danhof, Meindert
Formato:	Texto
Lenguaje:	English
Publicado:	Springer US 2007
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190336/ https://www.ncbi.nlm.nih.gov/pubmed/17914664 http://dx.doi.org/10.1007/s11095-007-9440-z

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