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Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management

BACKGROUND: The use of fine needle biopsy (FNB) for the diagnosis of metastatic melanoma can lead to the early removal and treatment of metastases, reduce the frequency of unnecessary surgery, and facilitate the staging of patients enrolled in clinical trials of adjuvant therapies. In this study, th...

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Autores principales: Doubrovsky, Anna, Scolyer, Richard A., Murali, Rajmohan, McKenzie, Paul R., Watson, Geoffrey F., Lee, C. Soon, McLeod, Duncan J., McCarthy, William H., Uren, Roger F., Stretch, Jonathan R., Saw, Robyn P., Thompson, John F.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190340/
https://www.ncbi.nlm.nih.gov/pubmed/17990041
http://dx.doi.org/10.1245/s10434-006-9341-0
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author Doubrovsky, Anna
Scolyer, Richard A.
Murali, Rajmohan
McKenzie, Paul R.
Watson, Geoffrey F.
Lee, C. Soon
McLeod, Duncan J.
McCarthy, William H.
Uren, Roger F.
Stretch, Jonathan R.
Saw, Robyn P.
Thompson, John F.
author_facet Doubrovsky, Anna
Scolyer, Richard A.
Murali, Rajmohan
McKenzie, Paul R.
Watson, Geoffrey F.
Lee, C. Soon
McLeod, Duncan J.
McCarthy, William H.
Uren, Roger F.
Stretch, Jonathan R.
Saw, Robyn P.
Thompson, John F.
author_sort Doubrovsky, Anna
collection PubMed
description BACKGROUND: The use of fine needle biopsy (FNB) for the diagnosis of metastatic melanoma can lead to the early removal and treatment of metastases, reduce the frequency of unnecessary surgery, and facilitate the staging of patients enrolled in clinical trials of adjuvant therapies. In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated. METHODS: A retrospective cohort study was performed with 2204 consecutive FNBs performed on 1416 patients known or suspected to have metastatic melanoma. Almost three-quarters (1582) of these FNBs were verified by either histopathologic diagnosis following surgical resection or clinical follow-up. RESULTS: FNB for metastatic melanoma was found to have an overall sensitivity of 92.1% and a specificity of 99.2%, with 69 false-negative and 5 false-positive findings identified. The sensitivity of the procedure was found to be influenced by six factors. The use of immunostains, reporting of the specimen by a cytopathologist who had reported >500 cases, lesions located in the skin and subcutis, and patients with ulcerated primary melanomas were factors associated with a significant improvement in the sensitivity of the test. However, FNBs performed in masses located in lymph nodes of the axilla and FNBs that required more than one needle pass to obtain a sample were far more likely to result in false-negative results. CONCLUSIONS: FNB is a rapid, accurate, and clinically useful technique for the assessment of disease status in patients with suspected metastatic melanoma.
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spelling pubmed-21903402008-01-28 Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management Doubrovsky, Anna Scolyer, Richard A. Murali, Rajmohan McKenzie, Paul R. Watson, Geoffrey F. Lee, C. Soon McLeod, Duncan J. McCarthy, William H. Uren, Roger F. Stretch, Jonathan R. Saw, Robyn P. Thompson, John F. Ann Surg Oncol Article BACKGROUND: The use of fine needle biopsy (FNB) for the diagnosis of metastatic melanoma can lead to the early removal and treatment of metastases, reduce the frequency of unnecessary surgery, and facilitate the staging of patients enrolled in clinical trials of adjuvant therapies. In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated. METHODS: A retrospective cohort study was performed with 2204 consecutive FNBs performed on 1416 patients known or suspected to have metastatic melanoma. Almost three-quarters (1582) of these FNBs were verified by either histopathologic diagnosis following surgical resection or clinical follow-up. RESULTS: FNB for metastatic melanoma was found to have an overall sensitivity of 92.1% and a specificity of 99.2%, with 69 false-negative and 5 false-positive findings identified. The sensitivity of the procedure was found to be influenced by six factors. The use of immunostains, reporting of the specimen by a cytopathologist who had reported >500 cases, lesions located in the skin and subcutis, and patients with ulcerated primary melanomas were factors associated with a significant improvement in the sensitivity of the test. However, FNBs performed in masses located in lymph nodes of the axilla and FNBs that required more than one needle pass to obtain a sample were far more likely to result in false-negative results. CONCLUSIONS: FNB is a rapid, accurate, and clinically useful technique for the assessment of disease status in patients with suspected metastatic melanoma. Springer-Verlag 2007-11-08 2008-01 /pmc/articles/PMC2190340/ /pubmed/17990041 http://dx.doi.org/10.1245/s10434-006-9341-0 Text en © Society of Surgical Oncology 2007
spellingShingle Article
Doubrovsky, Anna
Scolyer, Richard A.
Murali, Rajmohan
McKenzie, Paul R.
Watson, Geoffrey F.
Lee, C. Soon
McLeod, Duncan J.
McCarthy, William H.
Uren, Roger F.
Stretch, Jonathan R.
Saw, Robyn P.
Thompson, John F.
Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management
title Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management
title_full Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management
title_fullStr Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management
title_full_unstemmed Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management
title_short Diagnostic Accuracy of Fine Needle Biopsy for Metastatic Melanoma and Its Implications for Patient Management
title_sort diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190340/
https://www.ncbi.nlm.nih.gov/pubmed/17990041
http://dx.doi.org/10.1245/s10434-006-9341-0
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