Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing

Light chains isolated from normal immunoglobulin of unimmunized mice were analyzed by gel isoelectric focusing. Examination of the focusing patterns of light chains from nine inbred mouse strains showed that six of the strains (SWR/J, C3H/HeJ, DBA/1J, A/J, CBA/J, and C57BL/6J) possessed a virtually...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190346/
https://www.ncbi.nlm.nih.gov/pubmed/819613
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collection PubMed
description Light chains isolated from normal immunoglobulin of unimmunized mice were analyzed by gel isoelectric focusing. Examination of the focusing patterns of light chains from nine inbred mouse strains showed that six of the strains (SWR/J, C3H/HeJ, DBA/1J, A/J, CBA/J, and C57BL/6J) possessed a virtually identical spectrum of focusing bands, while the remaining three strains (RF/J, AKR/J, and C58/J) showed clear differences involving several bands. Analysis of the light chains of individual SWR/J, C58/J, and F1 hybrid mice indicated that the differences in focusing pattern were inherited in a simple codominant fashion. A new procedure was developed for the rapid analysis of light chains from small quantities of serum.
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spelling pubmed-21903462008-04-17 Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing J Exp Med Articles Light chains isolated from normal immunoglobulin of unimmunized mice were analyzed by gel isoelectric focusing. Examination of the focusing patterns of light chains from nine inbred mouse strains showed that six of the strains (SWR/J, C3H/HeJ, DBA/1J, A/J, CBA/J, and C57BL/6J) possessed a virtually identical spectrum of focusing bands, while the remaining three strains (RF/J, AKR/J, and C58/J) showed clear differences involving several bands. Analysis of the light chains of individual SWR/J, C58/J, and F1 hybrid mice indicated that the differences in focusing pattern were inherited in a simple codominant fashion. A new procedure was developed for the rapid analysis of light chains from small quantities of serum. The Rockefeller University Press 1976-07-01 /pmc/articles/PMC2190346/ /pubmed/819613 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
title Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
title_full Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
title_fullStr Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
title_full_unstemmed Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
title_short Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
title_sort genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190346/
https://www.ncbi.nlm.nih.gov/pubmed/819613

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