Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance

The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effe...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190369/
https://www.ncbi.nlm.nih.gov/pubmed/1084409
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description The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C' and the helper T cells with anti-Ly-2.2 and C'. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.
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spelling pubmed-21903692008-04-17 Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance J Exp Med Articles The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C' and the helper T cells with anti-Ly-2.2 and C'. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed. The Rockefeller University Press 1976-07-01 /pmc/articles/PMC2190369/ /pubmed/1084409 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance
title Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance
title_full Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance
title_fullStr Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance
title_full_unstemmed Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance
title_short Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance
title_sort differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of b-cell tolerance
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190369/
https://www.ncbi.nlm.nih.gov/pubmed/1084409

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