Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf

Structural variation in the second component of human complement was identified in about 4% of serum samples from random unrelated individuals of all the major races. Three forms of C2 have been identified by isoelectric focusing in polyacrylamide gel and development of patterns in agarose gel conta...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190428/
https://www.ncbi.nlm.nih.gov/pubmed/978135
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collection PubMed
description Structural variation in the second component of human complement was identified in about 4% of serum samples from random unrelated individuals of all the major races. Three forms of C2 have been identified by isoelectric focusing in polyacrylamide gel and development of patterns in agarose gel containing antibody-sensitized sheep red cells and C2-deficient serum: C2 C (common), C2 A (acidic), and C2 B (basic). The C2 variants were shown to be inherited as autosomal codominant traits, and suggestive evidence for close linkage between C2 and Bf was obtained.
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spelling pubmed-21904282008-04-17 Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf J Exp Med Articles Structural variation in the second component of human complement was identified in about 4% of serum samples from random unrelated individuals of all the major races. Three forms of C2 have been identified by isoelectric focusing in polyacrylamide gel and development of patterns in agarose gel containing antibody-sensitized sheep red cells and C2-deficient serum: C2 C (common), C2 A (acidic), and C2 B (basic). The C2 variants were shown to be inherited as autosomal codominant traits, and suggestive evidence for close linkage between C2 and Bf was obtained. The Rockefeller University Press 1976-10-01 /pmc/articles/PMC2190428/ /pubmed/978135 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf
title Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf
title_full Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf
title_fullStr Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf
title_full_unstemmed Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf
title_short Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf
title_sort inherited structural polymorphism in human c2: evidence for genetic linkage between c2 and bf
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190428/
https://www.ncbi.nlm.nih.gov/pubmed/978135

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