Cargando…

Induction and abrogation of unresponsiveness in nude mouse cells

Nude mice were injected with antigen and T cells at different times to induce unresponsiveness to SRBC. Spleen cells derived from these mice were tested in vitro for the capability to produce antibody-forming cells against sheep erythrocytes in the presence of a T-cell-replacing factor. It was found...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190472/
https://www.ncbi.nlm.nih.gov/pubmed/1087326
_version_ 1782146812044378112
collection PubMed
description Nude mice were injected with antigen and T cells at different times to induce unresponsiveness to SRBC. Spleen cells derived from these mice were tested in vitro for the capability to produce antibody-forming cells against sheep erythrocytes in the presence of a T-cell-replacing factor. It was found that priming with antigen alone did not result in paralysis but a later injection of thymus-derived lymphocytes together with antigen results in unresponsiveness of these cells in vitro, provided there was an interval of several days between the in vivo administration of thymus lymphocytes and the explantations of cells to in vitro cultures.
format Text
id pubmed-2190472
institution National Center for Biotechnology Information
language English
publishDate 1976
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21904722008-04-17 Induction and abrogation of unresponsiveness in nude mouse cells J Exp Med Articles Nude mice were injected with antigen and T cells at different times to induce unresponsiveness to SRBC. Spleen cells derived from these mice were tested in vitro for the capability to produce antibody-forming cells against sheep erythrocytes in the presence of a T-cell-replacing factor. It was found that priming with antigen alone did not result in paralysis but a later injection of thymus-derived lymphocytes together with antigen results in unresponsiveness of these cells in vitro, provided there was an interval of several days between the in vivo administration of thymus lymphocytes and the explantations of cells to in vitro cultures. The Rockefeller University Press 1976-12-01 /pmc/articles/PMC2190472/ /pubmed/1087326 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Induction and abrogation of unresponsiveness in nude mouse cells
title Induction and abrogation of unresponsiveness in nude mouse cells
title_full Induction and abrogation of unresponsiveness in nude mouse cells
title_fullStr Induction and abrogation of unresponsiveness in nude mouse cells
title_full_unstemmed Induction and abrogation of unresponsiveness in nude mouse cells
title_short Induction and abrogation of unresponsiveness in nude mouse cells
title_sort induction and abrogation of unresponsiveness in nude mouse cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190472/
https://www.ncbi.nlm.nih.gov/pubmed/1087326