Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen

The humoral response of nude spleen cells (b cells) to sheep erythrocytes was measured in the presence of varying numbers of concanavalin A (ConA)-acvated stimulatory spleen T cells (helper) and Con A-activated inhibitory spleen T cells (suppressor) from BDF1 mice. It was found that suppressive effe...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190518/
https://www.ncbi.nlm.nih.gov/pubmed/1078696
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description The humoral response of nude spleen cells (b cells) to sheep erythrocytes was measured in the presence of varying numbers of concanavalin A (ConA)-acvated stimulatory spleen T cells (helper) and Con A-activated inhibitory spleen T cells (suppressor) from BDF1 mice. It was found that suppressive effects could be reversed by the presence of additional numbers of stimulatory cells. These results seem incompatible with the hypothesis that suppression is mediated by supraoptimal numbers of stimulatory cells and provides additional evidence that separate populations of T cells mediate stimulation and suppression.
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spelling pubmed-21905182008-04-17 Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen J Exp Med Articles The humoral response of nude spleen cells (b cells) to sheep erythrocytes was measured in the presence of varying numbers of concanavalin A (ConA)-acvated stimulatory spleen T cells (helper) and Con A-activated inhibitory spleen T cells (suppressor) from BDF1 mice. It was found that suppressive effects could be reversed by the presence of additional numbers of stimulatory cells. These results seem incompatible with the hypothesis that suppression is mediated by supraoptimal numbers of stimulatory cells and provides additional evidence that separate populations of T cells mediate stimulation and suppression. The Rockefeller University Press 1975-02-01 /pmc/articles/PMC2190518/ /pubmed/1078696 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
title Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
title_full Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
title_fullStr Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
title_full_unstemmed Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
title_short Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
title_sort competition between concanavalin a-induced stimulatory and inhibitory effects in the in vitro immune response to antigen
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190518/
https://www.ncbi.nlm.nih.gov/pubmed/1078696

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