Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity

Serological cross-reactivity between the products of the H-2K and H-2D genes has been demonstrated by a design in which antibody was produced against determinants controlled by one locus (e .g . H-2K(k)), and then tested against the product of the opposite locus (e .g . H-2D(d)). A total of 13 out o...

Descripción completa

Detalles Bibliográficos
Autores principales: Murphy, DB, Shreffler, DC
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1975
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190532/
https://www.ncbi.nlm.nih.gov/pubmed/1089744
_version_ 1782146826169745408
author Murphy, DB
Shreffler, DC
author_facet Murphy, DB
Shreffler, DC
author_sort Murphy, DB
collection PubMed
description Serological cross-reactivity between the products of the H-2K and H-2D genes has been demonstrated by a design in which antibody was produced against determinants controlled by one locus (e .g . H-2K(k)), and then tested against the product of the opposite locus (e .g . H-2D(d)). A total of 13 out of 18 such test combinations exhibited H-2K-H-2D cross-reactivity. The presence or absence of cross-reactivity was reciprocal in most cases (i.e. antibody directed against the H-2K(k) gene product reacted with H-2(d) determinants, and antibody directed against the H-2D(d) gene product reacted with H-2K(k) determinants). An Ia-like reaction was detected with one antiserum which implied possible cross-reactivity between the products of two discrete la genes.
format Text
id pubmed-2190532
institution National Center for Biotechnology Information
language English
publishDate 1975
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21905322008-04-17 Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity Murphy, DB Shreffler, DC J Exp Med Articles Serological cross-reactivity between the products of the H-2K and H-2D genes has been demonstrated by a design in which antibody was produced against determinants controlled by one locus (e .g . H-2K(k)), and then tested against the product of the opposite locus (e .g . H-2D(d)). A total of 13 out of 18 such test combinations exhibited H-2K-H-2D cross-reactivity. The presence or absence of cross-reactivity was reciprocal in most cases (i.e. antibody directed against the H-2K(k) gene product reacted with H-2(d) determinants, and antibody directed against the H-2D(d) gene product reacted with H-2K(k) determinants). An Ia-like reaction was detected with one antiserum which implied possible cross-reactivity between the products of two discrete la genes. The Rockefeller University Press 1975-02-01 /pmc/articles/PMC2190532/ /pubmed/1089744 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Murphy, DB
Shreffler, DC
Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity
title Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity
title_full Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity
title_fullStr Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity
title_full_unstemmed Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity
title_short Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity
title_sort cross-reactivity between h-2k and h-2d products. i. evidence for extensive and reciprocal serological cross-reactivity
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190532/
https://www.ncbi.nlm.nih.gov/pubmed/1089744
work_keys_str_mv AT murphydb crossreactivitybetweenh2kandh2dproductsievidenceforextensiveandreciprocalserologicalcrossreactivity
AT shrefflerdc crossreactivitybetweenh2kandh2dproductsievidenceforextensiveandreciprocalserologicalcrossreactivity

Ejemplares similares