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Changes in DNA repair during aging
DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190694/ https://www.ncbi.nlm.nih.gov/pubmed/17913742 http://dx.doi.org/10.1093/nar/gkm756 |
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author | Gorbunova, Vera Seluanov, Andrei Mao, Zhiyong Hine, Christpher |
author_facet | Gorbunova, Vera Seluanov, Andrei Mao, Zhiyong Hine, Christpher |
author_sort | Gorbunova, Vera |
collection | PubMed |
description | DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved elaborate DNA repair machinery. Paradoxically, DNA repair can itself be subject to age-related changes and deterioration. In this review we will discuss the changes in efficiency of mismatch repair (MMR), base excision repair (BER), nucleotide excision repair (NER) and double-strand break (DSB) repair systems during aging, and potential changes in DSB repair pathway usage that occur with age. Mutations in DNA repair genes and premature aging phenotypes they cause have been reviewed extensively elsewhere, therefore the focus of this review is on the comparison of DNA repair mechanisms in young versus old. |
format | Text |
id | pubmed-2190694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21906942008-01-25 Changes in DNA repair during aging Gorbunova, Vera Seluanov, Andrei Mao, Zhiyong Hine, Christpher Nucleic Acids Res Survey and Summary DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved elaborate DNA repair machinery. Paradoxically, DNA repair can itself be subject to age-related changes and deterioration. In this review we will discuss the changes in efficiency of mismatch repair (MMR), base excision repair (BER), nucleotide excision repair (NER) and double-strand break (DSB) repair systems during aging, and potential changes in DSB repair pathway usage that occur with age. Mutations in DNA repair genes and premature aging phenotypes they cause have been reviewed extensively elsewhere, therefore the focus of this review is on the comparison of DNA repair mechanisms in young versus old. Oxford University Press 2007-12 2007-10-02 /pmc/articles/PMC2190694/ /pubmed/17913742 http://dx.doi.org/10.1093/nar/gkm756 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Survey and Summary Gorbunova, Vera Seluanov, Andrei Mao, Zhiyong Hine, Christpher Changes in DNA repair during aging |
title | Changes in DNA repair during aging |
title_full | Changes in DNA repair during aging |
title_fullStr | Changes in DNA repair during aging |
title_full_unstemmed | Changes in DNA repair during aging |
title_short | Changes in DNA repair during aging |
title_sort | changes in dna repair during aging |
topic | Survey and Summary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190694/ https://www.ncbi.nlm.nih.gov/pubmed/17913742 http://dx.doi.org/10.1093/nar/gkm756 |
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