Poly(ADP-ribosyl)ation in mammalian ageing

Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of co...

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Detalles Bibliográficos
Autores principales: Beneke, Sascha, Bürkle, Alexander
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190698/
https://www.ncbi.nlm.nih.gov/pubmed/17913748
http://dx.doi.org/10.1093/nar/gkm735
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author Beneke, Sascha
Bürkle, Alexander
author_facet Beneke, Sascha
Bürkle, Alexander
author_sort Beneke, Sascha
collection PubMed
description Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.
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spelling pubmed-21906982008-01-25 Poly(ADP-ribosyl)ation in mammalian ageing Beneke, Sascha Bürkle, Alexander Nucleic Acids Res Survey and Summary Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing. Oxford University Press 2007-12 2007-10-02 /pmc/articles/PMC2190698/ /pubmed/17913748 http://dx.doi.org/10.1093/nar/gkm735 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Beneke, Sascha
Bürkle, Alexander
Poly(ADP-ribosyl)ation in mammalian ageing
title Poly(ADP-ribosyl)ation in mammalian ageing
title_full Poly(ADP-ribosyl)ation in mammalian ageing
title_fullStr Poly(ADP-ribosyl)ation in mammalian ageing
title_full_unstemmed Poly(ADP-ribosyl)ation in mammalian ageing
title_short Poly(ADP-ribosyl)ation in mammalian ageing
title_sort poly(adp-ribosyl)ation in mammalian ageing
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190698/
https://www.ncbi.nlm.nih.gov/pubmed/17913748
http://dx.doi.org/10.1093/nar/gkm735
work_keys_str_mv AT benekesascha polyadpribosylationinmammalianageing
AT burklealexander polyadpribosylationinmammalianageing

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