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Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency
Ionizing radiation induces clustered DNA damage, which presents a challenge to the cellular repair machinery. The repair efficiency of a single-strand break (SSB) is ∼4× less than that for repair of an abasic (AP) site when in a bistranded cluster containing 8-oxoG. To explore whether this differenc...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190709/ https://www.ncbi.nlm.nih.gov/pubmed/17982170 http://dx.doi.org/10.1093/nar/gkm947 |