Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

Genome integrity is constantly threatened by DNA lesions arising from numerous exogenous and endogenous sources. Survival depends on immediate recognition of these lesions and rapid recruitment of repair factors. Using laser microirradiation and live cell microscopy we found that the DNA-damage depe...

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Detalles Bibliográficos
Autores principales: Mortusewicz, Oliver, Amé, Jean-Christophe, Schreiber, Valérie, Leonhardt, Heinrich
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190722/
https://www.ncbi.nlm.nih.gov/pubmed/17982172
http://dx.doi.org/10.1093/nar/gkm933

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