The ageing mitochondrial genome

The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding th...

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Detalles Bibliográficos
Autores principales: Krishnan, Kim J., Greaves, Laura C., Reeve, Amy K., Turnbull, Doug
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190723/
https://www.ncbi.nlm.nih.gov/pubmed/17913753
http://dx.doi.org/10.1093/nar/gkm635
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author Krishnan, Kim J.
Greaves, Laura C.
Reeve, Amy K.
Turnbull, Doug
author_facet Krishnan, Kim J.
Greaves, Laura C.
Reeve, Amy K.
Turnbull, Doug
author_sort Krishnan, Kim J.
collection PubMed
description The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process. One plausible mechanism for ageing is accumulation of mutations in the mitochondrial genome. In this review, we discuss some of the most convincing data surrounding age-related mtDNA mutations and the evidence that these mutations contribute to the ageing process.
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spelling pubmed-21907232008-01-25 The ageing mitochondrial genome Krishnan, Kim J. Greaves, Laura C. Reeve, Amy K. Turnbull, Doug Nucleic Acids Res Survey and Summary The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process. One plausible mechanism for ageing is accumulation of mutations in the mitochondrial genome. In this review, we discuss some of the most convincing data surrounding age-related mtDNA mutations and the evidence that these mutations contribute to the ageing process. Oxford University Press 2007-12 2007-10-02 /pmc/articles/PMC2190723/ /pubmed/17913753 http://dx.doi.org/10.1093/nar/gkm635 Text en © 2007 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Krishnan, Kim J.
Greaves, Laura C.
Reeve, Amy K.
Turnbull, Doug
The ageing mitochondrial genome
title The ageing mitochondrial genome
title_full The ageing mitochondrial genome
title_fullStr The ageing mitochondrial genome
title_full_unstemmed The ageing mitochondrial genome
title_short The ageing mitochondrial genome
title_sort ageing mitochondrial genome
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190723/
https://www.ncbi.nlm.nih.gov/pubmed/17913753
http://dx.doi.org/10.1093/nar/gkm635
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