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The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule
The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport. The MHC recombinant lab...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1991
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190796/ https://www.ncbi.nlm.nih.gov/pubmed/2007857 |
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collection | PubMed |
description | The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport. The MHC recombinant laboratory rat strains PVG.R1 and PVG.R8 display unusually long retention of RT1.Aa within the endoplasmic reticulum or cis-Golgi. In appropriate F1 hybrid cells heterozygous for RT1.Aa and another class I MHC allele, RT1.Ac, only the RT1.Aa protein is subject to slow transport. The cim gene product therefore shows class I allele specificity in its action, cim appears to be a polymorphic locus whose product is directly involved in the processes of class I MHC assembly and/or intracellular transport. |
format | Text |
id | pubmed-2190796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21907962008-04-17 The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule J Exp Med Articles The dominant trans-acting major histocompatibility complex (MHC)-linked class I modifier (cim) locus, previously recognized through its ability to determine altered alloantigenicity of a rat class I molecule, RT1.A3, is shown here to influence class I intracellular transport. The MHC recombinant laboratory rat strains PVG.R1 and PVG.R8 display unusually long retention of RT1.Aa within the endoplasmic reticulum or cis-Golgi. In appropriate F1 hybrid cells heterozygous for RT1.Aa and another class I MHC allele, RT1.Ac, only the RT1.Aa protein is subject to slow transport. The cim gene product therefore shows class I allele specificity in its action, cim appears to be a polymorphic locus whose product is directly involved in the processes of class I MHC assembly and/or intracellular transport. The Rockefeller University Press 1991-04-01 /pmc/articles/PMC2190796/ /pubmed/2007857 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule |
title | The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule |
title_full | The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule |
title_fullStr | The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule |
title_full_unstemmed | The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule |
title_short | The major histocompatibility complex class II-linked cim locus controls the kinetics of intracellular transport of a classical class I molecule |
title_sort | major histocompatibility complex class ii-linked cim locus controls the kinetics of intracellular transport of a classical class i molecule |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190796/ https://www.ncbi.nlm.nih.gov/pubmed/2007857 |