Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line

The chromosome breakpoints of a translocation, t(2;14), from an Epstein- Barr virus-transformed human B lymphoblastoid cell line were isolated and analyzed. This unusual translocation arose as a result of the fusion of two immunoglobulin (Ig) variable (V) genes, one from the heavy chain cluster on c...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190807/
https://www.ncbi.nlm.nih.gov/pubmed/1840606
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collection PubMed
description The chromosome breakpoints of a translocation, t(2;14), from an Epstein- Barr virus-transformed human B lymphoblastoid cell line were isolated and analyzed. This unusual translocation arose as a result of the fusion of two immunoglobulin (Ig) variable (V) genes, one from the heavy chain cluster on chromosome 14, the other from the light chain (k) cluster on chromosome 2. The chromosome breaks occurred within the coding sequence of each gene, and there was no obvious evidence for lymphoid V(D)J recombinase involvement in the translocation. This suggests that breakage and rejoining of the involved V genes occurred by some process other than that which normally rearranges Ig genes.
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spelling pubmed-21908072008-04-17 Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line J Exp Med Articles The chromosome breakpoints of a translocation, t(2;14), from an Epstein- Barr virus-transformed human B lymphoblastoid cell line were isolated and analyzed. This unusual translocation arose as a result of the fusion of two immunoglobulin (Ig) variable (V) genes, one from the heavy chain cluster on chromosome 14, the other from the light chain (k) cluster on chromosome 2. The chromosome breaks occurred within the coding sequence of each gene, and there was no obvious evidence for lymphoid V(D)J recombinase involvement in the translocation. This suggests that breakage and rejoining of the involved V genes occurred by some process other than that which normally rearranges Ig genes. The Rockefeller University Press 1991-04-01 /pmc/articles/PMC2190807/ /pubmed/1840606 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line
title Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line
title_full Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line
title_fullStr Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line
title_full_unstemmed Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line
title_short Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line
title_sort novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain v genes in a human b lymphoblastoid cell line
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190807/
https://www.ncbi.nlm.nih.gov/pubmed/1840606

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