Induction of autoreactive B cells allows priming of autoreactive T cells

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non- self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190847/
https://www.ncbi.nlm.nih.gov/pubmed/1851798
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collection PubMed
description A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non- self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.
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spelling pubmed-21908472008-04-17 Induction of autoreactive B cells allows priming of autoreactive T cells J Exp Med Articles A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non- self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen. The Rockefeller University Press 1991-06-01 /pmc/articles/PMC2190847/ /pubmed/1851798 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Induction of autoreactive B cells allows priming of autoreactive T cells
title Induction of autoreactive B cells allows priming of autoreactive T cells
title_full Induction of autoreactive B cells allows priming of autoreactive T cells
title_fullStr Induction of autoreactive B cells allows priming of autoreactive T cells
title_full_unstemmed Induction of autoreactive B cells allows priming of autoreactive T cells
title_short Induction of autoreactive B cells allows priming of autoreactive T cells
title_sort induction of autoreactive b cells allows priming of autoreactive t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190847/
https://www.ncbi.nlm.nih.gov/pubmed/1851798

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