Thymus epithelium induces tissue-specific tolerance

Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize ant...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1993
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190970/
https://www.ncbi.nlm.nih.gov/pubmed/8459209
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collection PubMed
description Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.
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spelling pubmed-21909702008-04-16 Thymus epithelium induces tissue-specific tolerance J Exp Med Articles Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells. The Rockefeller University Press 1993-04-01 /pmc/articles/PMC2190970/ /pubmed/8459209 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Thymus epithelium induces tissue-specific tolerance
title Thymus epithelium induces tissue-specific tolerance
title_full Thymus epithelium induces tissue-specific tolerance
title_fullStr Thymus epithelium induces tissue-specific tolerance
title_full_unstemmed Thymus epithelium induces tissue-specific tolerance
title_short Thymus epithelium induces tissue-specific tolerance
title_sort thymus epithelium induces tissue-specific tolerance
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190970/
https://www.ncbi.nlm.nih.gov/pubmed/8459209

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