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Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene
The MRL-lpr/lpr mouse strain is a model of systemic autoimmune disease. In this model, intrinsic defects of intrathymic T cell development include defective deletion of self-reactive T cells and expression of endogenous retroviruses. Defective deletion of self-reactive T cells in the thymus has been...
| Formato: | Texto |
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| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1993
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191111/ https://www.ncbi.nlm.nih.gov/pubmed/7688023 |