Cargando…
CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4
Type 1 and type 2 cloned T helper (Th) cells are believed to require different antigen-presenting cell (APC)-derived costimuli for proliferation. In the case of Th1-cloned T cells, CD28 signaling costimulates production of autocrine interleukin 2 (IL-2). Th2 cells produce their autocrine growth fact...
Formato: | Texto |
---|---|
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1993
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191256/ https://www.ncbi.nlm.nih.gov/pubmed/8228811 |
_version_ | 1782146962304270336 |
---|---|
collection | PubMed |
description | Type 1 and type 2 cloned T helper (Th) cells are believed to require different antigen-presenting cell (APC)-derived costimuli for proliferation. In the case of Th1-cloned T cells, CD28 signaling costimulates production of autocrine interleukin 2 (IL-2). Th2 cells produce their autocrine growth factor, IL-4, without costimulation, but require APC-derived costimuli, or IL-1, to respond to IL-4. Here we demonstrate that engagement of CD28 on Th2 cells with anti-CD28 antibody or with APC-associated B7 costimulates Th2 responsiveness to IL-4 but does not affect IL-4 or IL-2 production by Th2 cells. Costimulation of Th2 cells via CD28 appears to involve the induction of IL-1 production by Th2 cells, which acts in an autocrine fashion to induce IL-4 responsiveness. These results suggest that CD28-induced costimulation plays an important role in responses mediated by both types of Th cells. |
format | Text |
id | pubmed-2191256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1993 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21912562008-04-16 CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 J Exp Med Articles Type 1 and type 2 cloned T helper (Th) cells are believed to require different antigen-presenting cell (APC)-derived costimuli for proliferation. In the case of Th1-cloned T cells, CD28 signaling costimulates production of autocrine interleukin 2 (IL-2). Th2 cells produce their autocrine growth factor, IL-4, without costimulation, but require APC-derived costimuli, or IL-1, to respond to IL-4. Here we demonstrate that engagement of CD28 on Th2 cells with anti-CD28 antibody or with APC-associated B7 costimulates Th2 responsiveness to IL-4 but does not affect IL-4 or IL-2 production by Th2 cells. Costimulation of Th2 cells via CD28 appears to involve the induction of IL-1 production by Th2 cells, which acts in an autocrine fashion to induce IL-4 responsiveness. These results suggest that CD28-induced costimulation plays an important role in responses mediated by both types of Th cells. The Rockefeller University Press 1993-11-01 /pmc/articles/PMC2191256/ /pubmed/8228811 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
title | CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
title_full | CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
title_fullStr | CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
title_full_unstemmed | CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
title_short | CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
title_sort | cd28-induced costimulation of t helper type 2 cells mediated by induction of responsiveness to interleukin 4 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191256/ https://www.ncbi.nlm.nih.gov/pubmed/8228811 |