Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantati...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1994
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191400/ https://www.ncbi.nlm.nih.gov/pubmed/7906704 |
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collection | PubMed |
description | The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs. |
format | Text |
id | pubmed-2191400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21914002008-04-16 Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder J Exp Med Articles The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs. The Rockefeller University Press 1994-03-01 /pmc/articles/PMC2191400/ /pubmed/7906704 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
title | Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
title_full | Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
title_fullStr | Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
title_full_unstemmed | Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
title_short | Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
title_sort | focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191400/ https://www.ncbi.nlm.nih.gov/pubmed/7906704 |