Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder

The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantati...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1994
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191400/
https://www.ncbi.nlm.nih.gov/pubmed/7906704
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description The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.
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spelling pubmed-21914002008-04-16 Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder J Exp Med Articles The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs. The Rockefeller University Press 1994-03-01 /pmc/articles/PMC2191400/ /pubmed/7906704 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
title Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
title_full Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
title_fullStr Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
title_full_unstemmed Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
title_short Focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
title_sort focal segmental glomerular sclerosis, a type of intractable chronic glomerulonephritis, is a stem cell disorder
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191400/
https://www.ncbi.nlm.nih.gov/pubmed/7906704

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