NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80

Natural killer (NK) cell clones have been previously described which are inhibited by HLA-C alleles with Asn77-Lys80 (NK1-specific cells) or by HLA-C alleles with Ser77-Asn80 (NK2-specific cells). In the present work, the generation of NK cells with HLA-B-related specificities was attempted by stimu...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1994
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191670/
https://www.ncbi.nlm.nih.gov/pubmed/7931060
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collection PubMed
description Natural killer (NK) cell clones have been previously described which are inhibited by HLA-C alleles with Asn77-Lys80 (NK1-specific cells) or by HLA-C alleles with Ser77-Asn80 (NK2-specific cells). In the present work, the generation of NK cells with HLA-B-related specificities was attempted by stimulation of a Bw4 homozygous responder by a Bw6 homozygous donor. Two NK clones were found, which were inhibited by HLA- Bw4 (but not by HLA-Bw6) allotypes and by some HLA-A allotypes that share the Bw4 public epitope. Inhibition of NK cell-mediated lysis strongly correlated with the presence of an Ile residue at position 80 of the protective allele. These NK cell clones define a new specificity termed NK3.
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spelling pubmed-21916702008-04-16 NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80 J Exp Med Articles Natural killer (NK) cell clones have been previously described which are inhibited by HLA-C alleles with Asn77-Lys80 (NK1-specific cells) or by HLA-C alleles with Ser77-Asn80 (NK2-specific cells). In the present work, the generation of NK cells with HLA-B-related specificities was attempted by stimulation of a Bw4 homozygous responder by a Bw6 homozygous donor. Two NK clones were found, which were inhibited by HLA- Bw4 (but not by HLA-Bw6) allotypes and by some HLA-A allotypes that share the Bw4 public epitope. Inhibition of NK cell-mediated lysis strongly correlated with the presence of an Ile residue at position 80 of the protective allele. These NK cell clones define a new specificity termed NK3. The Rockefeller University Press 1994-10-01 /pmc/articles/PMC2191670/ /pubmed/7931060 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80
title NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80
title_full NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80
title_fullStr NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80
title_full_unstemmed NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80
title_short NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80
title_sort nk3-specific natural killer cells are selectively inhibited by bw4- positive hla alleles with isoleucine 80
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191670/
https://www.ncbi.nlm.nih.gov/pubmed/7931060

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