Cargando…

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor

Interleukin 15 (IL-15) is a novel cytokine that has recently been cloned and expressed. Whereas it has no sequence homology with IL-2, IL- 15 interacts with components of the IL-2 receptor (IL-2R). In the present study we performed a functional analysis of recombinant IL-15 on phenotypically and fun...

Descripción completa

Detalles Bibliográficos
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1994
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191697/ https://www.ncbi.nlm.nih.gov/pubmed/7523571

Ejemplares similares

The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors
por: de Rham, Casimir, et al.
Publicado: (2007)

Effect of interleukins (IL-2, IL-15, IL-18) on receptors activation and cytotoxic activity of natural killer cells in breast cancer cell
por: Widowati, Wahyu, et al.
Publicado: (2020)

IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
por: Choi, Yeon Ho, et al.
Publicado: (2019)

Correction to: IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
por: Choi, Yeon Ho, et al.
Publicado: (2019)

Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity
por: Van den Bergh, Johan, et al.
Publicado: (2015)

Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice
por: Koka, Rima, et al.
Publicado: (2003)

Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15
Publicado: (1995)

A novel fusion protein scaffold 18/12/TxM activates the IL-12, IL-15, and IL-18 receptors to induce human memory-like natural killer cells
por: Cubitt, Celia C., et al.
Publicado: (2022)

Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8(+) T Cell Homeostasis
por: Burkett, Patrick R., et al.
Publicado: (2004)

Improving Clinical Manufacturing of IL-15 Activated Cytokine-Induced Killer (CIK) Cells
por: Bremm, Melanie, et al.
Publicado: (2019)

Mechanistic Model of Natural Killer Cell Proliferative Response to IL-15 Receptor Stimulation
por: Zhao, Yun M., et al.
Publicado: (2013)

Interleukin-15 (IL-15) and IL-15 receptor alpha fusion protein enhances antitumor activity of myxoma virus
por: Tosic, Vesna, et al.
Publicado: (2013)

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma
por: Wagner, Juliane, et al.
Publicado: (2017)

Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function
por: Zhang, Caimei, et al.
Publicado: (2023)

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
por: Junttila, Ilkka S.
Publicado: (2018)

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma
por: Farahani, Rahim, et al.
Publicado: (2014)

Interleukin (IL)-18 Binding Protein Deficiency Disrupts Natural Killer Cell Maturation and Diminishes Circulating IL-18
por: Harms, Robert Z., et al.
Publicado: (2017)

The effect of interleukin-15 on the expression of killer-cell immunoglobulin-like receptors on peripheral natural killer cells in human.
por: Kogure, Toshiaki, et al.
Publicado: (2002)

Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma
por: Zhuang, Lihui, et al.
Publicado: (2018)

Myxoma Virus Expressing a Fusion Protein of Interleukin-15 (IL15) and IL15 Receptor Alpha Has Enhanced Antitumor Activity
por: Tosic, Vesna, et al.
Publicado: (2014)

IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
por: Sharma, Archna, et al.
Publicado: (2013)

The Role of Interleukin-1 cytokine family (IL-1β, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis
por: Abushouk, Amir, et al.
Publicado: (2019)

Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-Like Cells in Systemic Lupus Erythematosis Regulation with Interleukin-15
por: Lin, Syh-Jae, et al.
Publicado: (2019)

IL‐12 and IL‐15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells
por: Hydes, Theresa, et al.
Publicado: (2017)

The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment
por: Nair, Savita, et al.
Publicado: (2015)

An activation-induced IL-15 isoform is a natural antagonist for IL-15 function
por: Zhao, Lei, et al.
Publicado: (2016)

Defective Interleukin (IL)-18–mediated Natural Killer and T Helper Cell Type 1 Responses in IL-1 Receptor–associated Kinase (IRAK)-deficient Mice
por: Kanakaraj, Palanisamy, et al.
Publicado: (1999)

The role of cytokines in seizures: interleukin (IL)-1β, IL-1Ra, IL-8, and IL-10
por: Youn, Youngah, et al.
Publicado: (2013)

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R
Publicado: (1992)

A Chimeric IL-15/IL-15Rα Molecule Expressed on NFκB-Activated Dendritic Cells Supports Their Capability to Activate Natural Killer Cells †
por: Bosch, Naomi C., et al.
Publicado: (2021)

Natural killer cells expanded on membrane-bound IL15 or IL21 activate different miRNA transcriptional profiles with functional consequences
por: Somanchi, Anitha, et al.
Publicado: (2015)

Interleukin-15, IL-15 Receptor-Alpha, and Obesity: Concordance of Laboratory Animal and Human Genetic Studies
por: Quinn, LeBris S., et al.
Publicado: (2011)

Signalling of multiple interleukin (IL)‐17 family cytokines via IL‐17 receptor A drives psoriasis‐related inflammatory pathways
por: Tollenaere, M.A.X., et al.
Publicado: (2021)

Activation of natural killer cells via the p75 interleukin 2 receptor
Publicado: (1989)

Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells
por: Terrén, Iñigo, et al.
Publicado: (2018)

Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response
por: Yamaguchi, Takuya, et al.
Publicado: (2020)

Ovalbumin induces natural killer cells to secrete Th2 cytokines IL-5 and IL-13 in a mouse model of asthma
por: Chen, Zhangbo, et al.
Publicado: (2019)

PDGF-D−PDGFRβ signaling enhances IL-15–mediated human natural killer cell survival
por: Ma, Shoubao, et al.
Publicado: (2022)

Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56(bright) Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation
por: Ziblat, Andrea, et al.
Publicado: (2018)

Sialylation of Human Natural Killer (NK) Cells Is Regulated by IL-2
por: Rosenstock, Philip, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tk82u903oum0q1vvs3rcib9h2r