Upregulation of surface markers on dying thymocytes

Using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) to detect cells undergoing early apoptosis, we have defined the surface markers expressed on CD4+CD8+ thymocytes undergoing spontaneous or steroid-induced apoptosis in tissue culture. Some surface markers, e.g...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191870/
https://www.ncbi.nlm.nih.gov/pubmed/7836919
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collection PubMed
description Using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) to detect cells undergoing early apoptosis, we have defined the surface markers expressed on CD4+CD8+ thymocytes undergoing spontaneous or steroid-induced apoptosis in tissue culture. Some surface markers, e.g., CD4, CD8, and heat stable antigen, are downregulated on apoptotic thymocytes. Surprisingly, however, other markers are upregulated; this applies to T cell receptor beta/CD3, CD69, and CD25 expression. Upregulation of these markers is restricted to a discrete subset of apoptotic cells.
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spelling pubmed-21918702008-04-16 Upregulation of surface markers on dying thymocytes J Exp Med Articles Using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) to detect cells undergoing early apoptosis, we have defined the surface markers expressed on CD4+CD8+ thymocytes undergoing spontaneous or steroid-induced apoptosis in tissue culture. Some surface markers, e.g., CD4, CD8, and heat stable antigen, are downregulated on apoptotic thymocytes. Surprisingly, however, other markers are upregulated; this applies to T cell receptor beta/CD3, CD69, and CD25 expression. Upregulation of these markers is restricted to a discrete subset of apoptotic cells. The Rockefeller University Press 1995-02-01 /pmc/articles/PMC2191870/ /pubmed/7836919 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Upregulation of surface markers on dying thymocytes
title Upregulation of surface markers on dying thymocytes
title_full Upregulation of surface markers on dying thymocytes
title_fullStr Upregulation of surface markers on dying thymocytes
title_full_unstemmed Upregulation of surface markers on dying thymocytes
title_short Upregulation of surface markers on dying thymocytes
title_sort upregulation of surface markers on dying thymocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191870/
https://www.ncbi.nlm.nih.gov/pubmed/7836919

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