Class II transactivator regulates the expression of multiple genes involved in antigen presentation

CIITA (a major histocompatibility complex [MHC] class II transactivator) has been shown to be required for the expression of MHC class II genes in both B cells and interferon gamma-inducible cells. Here we demonstrate that CIITA not only activates MHC class II genes but also genes required for antig...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191893/
https://www.ncbi.nlm.nih.gov/pubmed/7836928
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collection PubMed
description CIITA (a major histocompatibility complex [MHC] class II transactivator) has been shown to be required for the expression of MHC class II genes in both B cells and interferon gamma-inducible cells. Here we demonstrate that CIITA not only activates MHC class II genes but also genes required for antigen presentation. Mutant HeLa cells, defective in the expression of classic MHC class II genes, invariant chain, and the newly described human histocompatibility leukocyte antigen-DM genes, were used to study the role of CIITA in the regulation of these genes. Upon transfection with CIITA cDNA, the mutant cells expressed all three genes, suggesting that CIITA is a global regulator for the expression of genes involved in antigen presentation.
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spelling pubmed-21918932008-04-16 Class II transactivator regulates the expression of multiple genes involved in antigen presentation J Exp Med Articles CIITA (a major histocompatibility complex [MHC] class II transactivator) has been shown to be required for the expression of MHC class II genes in both B cells and interferon gamma-inducible cells. Here we demonstrate that CIITA not only activates MHC class II genes but also genes required for antigen presentation. Mutant HeLa cells, defective in the expression of classic MHC class II genes, invariant chain, and the newly described human histocompatibility leukocyte antigen-DM genes, were used to study the role of CIITA in the regulation of these genes. Upon transfection with CIITA cDNA, the mutant cells expressed all three genes, suggesting that CIITA is a global regulator for the expression of genes involved in antigen presentation. The Rockefeller University Press 1995-02-01 /pmc/articles/PMC2191893/ /pubmed/7836928 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Class II transactivator regulates the expression of multiple genes involved in antigen presentation
title Class II transactivator regulates the expression of multiple genes involved in antigen presentation
title_full Class II transactivator regulates the expression of multiple genes involved in antigen presentation
title_fullStr Class II transactivator regulates the expression of multiple genes involved in antigen presentation
title_full_unstemmed Class II transactivator regulates the expression of multiple genes involved in antigen presentation
title_short Class II transactivator regulates the expression of multiple genes involved in antigen presentation
title_sort class ii transactivator regulates the expression of multiple genes involved in antigen presentation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191893/
https://www.ncbi.nlm.nih.gov/pubmed/7836928

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