Chemoattraction of human blood T lymphocytes by interleukin-15

Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells in polarized morphology, to stimulate invasion of collagen gels containing IL-15, and to increase the propo...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1995
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191928/
https://www.ncbi.nlm.nih.gov/pubmed/7869044
_version_ 1782147120218767360
collection PubMed
description Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells in polarized morphology, to stimulate invasion of collagen gels containing IL-15, and to increase the proportion of locomotor cells observed by time-lapse videorecording. The ability of lymphocytes to respond was partly, but not completely, inhibited by pretreatment with anti-IL-2 receptor beta-chain. The activity of IL-15 was completely abolished by preincubation with aIL-15 but unaffected by preincubation with aIL-2. No response of monocytes, neutrophils, or B lymphocytes to IL-15 was observed.
format Text
id pubmed-2191928
institution National Center for Biotechnology Information
language English
publishDate 1995
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21919282008-04-16 Chemoattraction of human blood T lymphocytes by interleukin-15 J Exp Med Articles Recombinant interleukin (IL)-15, derived from a simian kidney epithelial cell line, is a chemoattractant for human blood T lymphocytes judged by its ability to increase the proportion of cells in polarized morphology, to stimulate invasion of collagen gels containing IL-15, and to increase the proportion of locomotor cells observed by time-lapse videorecording. The ability of lymphocytes to respond was partly, but not completely, inhibited by pretreatment with anti-IL-2 receptor beta-chain. The activity of IL-15 was completely abolished by preincubation with aIL-15 but unaffected by preincubation with aIL-2. No response of monocytes, neutrophils, or B lymphocytes to IL-15 was observed. The Rockefeller University Press 1995-03-01 /pmc/articles/PMC2191928/ /pubmed/7869044 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Chemoattraction of human blood T lymphocytes by interleukin-15
title Chemoattraction of human blood T lymphocytes by interleukin-15
title_full Chemoattraction of human blood T lymphocytes by interleukin-15
title_fullStr Chemoattraction of human blood T lymphocytes by interleukin-15
title_full_unstemmed Chemoattraction of human blood T lymphocytes by interleukin-15
title_short Chemoattraction of human blood T lymphocytes by interleukin-15
title_sort chemoattraction of human blood t lymphocytes by interleukin-15
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191928/
https://www.ncbi.nlm.nih.gov/pubmed/7869044

Ejemplares similares