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Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo
Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic pept...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1995
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191965/ https://www.ncbi.nlm.nih.gov/pubmed/7699337 |
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collection | PubMed |
description | Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic peptide or the major histocompatibility complex class II molecule can determine whether Th1-like or Th2-like responses are obtained. Our results show that peptide/major histocompatibility complex class II complexes that interact strongly with the T cell receptor favor generation of Th1-like cells, while those that bind weakly favor priming of Th2-like T cells. Thus, signals from the T cell receptor can influence the differentiation of CD4 T cells into specific types of effector cells. |
format | Text |
id | pubmed-2191965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21919652008-04-16 Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo J Exp Med Articles Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic peptide or the major histocompatibility complex class II molecule can determine whether Th1-like or Th2-like responses are obtained. Our results show that peptide/major histocompatibility complex class II complexes that interact strongly with the T cell receptor favor generation of Th1-like cells, while those that bind weakly favor priming of Th2-like T cells. Thus, signals from the T cell receptor can influence the differentiation of CD4 T cells into specific types of effector cells. The Rockefeller University Press 1995-04-01 /pmc/articles/PMC2191965/ /pubmed/7699337 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo |
title | Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo |
title_full | Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo |
title_fullStr | Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo |
title_full_unstemmed | Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo |
title_short | Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo |
title_sort | altered peptide ligands can control cd4 t lymphocyte differentiation in vivo |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191965/ https://www.ncbi.nlm.nih.gov/pubmed/7699337 |